スタッフ紹介

川内 潤也

Junya Kawauchi

ごあいさつ

こんにちは。わたクリニック医師の川内と申します。
もともと外科、とくに心臓血管外科を専攻しておりましたが、当クリニックに勤務する直前は主に転写・発癌メカニズムなどの研究と教育に携わっていました。

これまでに自分が歩んできた経験から感じることは、手術室で遭遇する出来事(外科医として)、細胞の中で起こっていることをしること(研究者として)、在宅医療の場で出会う出来事(現在)、すべての人間の神秘に触れる体験だということです。

これまでの経験を生かしながら、既成の概念にとらわれずに、患者さま本人の気持ちを優先し、フレキシブルに迅速に対応することを大事にしていきたいと思っています。

経歴

出身大学 東京医科歯科大学
専門分野 内科 外科 緩和医療 循環器内科 心臓血管外科
職歴等 東京医科歯科大学医学部付属病院
土浦協同病院
都立広尾病院
Oxford大学 Sir William Dunn School of Pathology
東京医科歯科大学難治疾患研究所
資格 医学博士
日本外科学会認定医(日本癌学会会員 日本在宅医学界開院 日本緩和医療学会会員)

業績など

論文

  1. Edagawa M, Kawauchi J, Hirata M, Goshima H, Inoue M, Okamoto T, Murakami A, Maehara Y, Kitajima S. Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J Biol Chem. 2014 Aug 1;289(31):21544-61.
  2. Kawauchi J, Inoue M, Fukuda M, Uchida Y, Yasukawa T, Conaway RC, Conaway JW, Aso T, Kitajima S. Transcriptional properties of mammalian elongin A and its role in stress response. J Biol Chem. 2013 Aug 23;288(34):24302-15.
  3. Yasukawa T, Bhatt S, Takeuchi T, Kawauchi J, Takahashi H, Tsutsui A, Muraoka T, Inoue M, Tsuda M, Kitajima S, Conaway RC, Conaway JW, Trainor PA, Aso T. Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation. Cell Rep. 2012 Nov 29;2(5):1129-36.
  4. Tanaka Y, Nakamura A, Morioka MS, Inoue S, Tamamori-Adachi M, Yamada K, Taketani K, Kawauchi J, Tanaka-Okamoto M, Miyoshi J, Tanaka H, Kitajima S. Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway. PLoS One. 2011;6(10):e26848.
  5. Taketani K, Kawauchi J, Tanaka-Okamoto M, Ishizaki H, Tanaka Y, Sakai T, Miyoshi J, Maehara Y, Kitajima S. Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells. Oncogene. 2012 Apr 26;31(17):2210-21.
  6. Braglia P, Kawauchi J, Proudfoot NJ. Co-transcriptional RNA cleavage provides a failsafe termination mechanism for yeast RNA polymerase I. Nucleic Acids Res. 2011 Mar;39(4):1439-48.
  7. Rondón AG, Mischo HE, Kawauchi J, Proudfoot NJ. Fail-safe transcriptional termination for protein-coding genes in S.cerevisiae. Mol Cell. 2009 Oct 9;36(1):88-98.
  8. Kawauchi J, Mischo H, Braglia P, Rondon A, Proudfoot NJ. Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination. Genes Dev. 2008 Apr 15;22(8):1082-92.
  9. Jones HS, Kawauchi J, Braglia P, Alen CM, Kent NA, Proudfoot NJ. RNA polymerase I in yeast transcribes dynamic nucleosomal rDNA. Nat Struct Mol Biol. 2007 Feb;14(2):123-30.
  10. Tamura K, Hua B, Adachi S, Guney I, Kawauchi J, Morioka M, Tamamori-Adachi M, Tanaka Y, Nakabeppu Y, Sunamori M, Sedivy JM, Kitajima S. Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. EMBO J. 2005 Jul 20;24(14):2590-601.
  11. Tamamori-Adachi M, Ito H, Sumrejkanchanakij P, Adachi S, Hiroe M, Shimizu M, Kawauchi J, Sunamori M, Marumo F, Kitajima S, Ikeda MA. Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res. 2003 Jan 10;92(1):e12-9.
  12. Nobori K, Ito H, Tamamori-Adachi M, Adachi S, Ono Y, Kawauchi J, Kitajima S, Marumo F, Isobe M. ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3. J Mol Cell Cardiol. 2002 Oct;34(10):1387-97.
  13. Zhang C, Gao C, Kawauchi J, Hashimoto Y, Tsuchida N, Kitajima S. Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53. Biochem Biophys Res Commun. 2002 Oct 11;297(5):1302-10.
  14. Tamamori-Adachi M, Ito H, Nobori K, Hayashida K, Kawauchi J, Adachi S, Ikeda MA, Kitajima S. Expression of cyclin D1 and CDK4 causes hypertrophic growth of cardiomyocytes in culture: a possible implication for cardiac hypertrophy. Biochem Biophys Res Commun. 2002 Aug 16;296(2):274-80.
  15. Kawauchi J, Zhang C, Nobori K, Hashimoto Y, Adachi MT, Noda A, Sunamori M, Kitajima S. Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription. J Biol Chem. 2002 Oct 11;277(41):39025-34.
  16. Hashimoto Y, Zhang C, Kawauchi J, Imoto I, Adachi MT, Inazawa J, Amagasa T, Hai T, Kitajima S. An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. Nucleic Acids Res. 2002 Jun 1;30(11):2398-406.
  17. Zhang C, Kawauchi J, Adachi MT, Hashimoto Y, Oshiro S, Aso T, Kitajima S. Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine. Biochem Biophys Res Commun. 2001 Dec 7;289(3):718-24.
  18. Tamura K, Nakahara H, Furukawa H, Kawauchi J. [Two cases of left main trunk lesion treated with coronary artery bypass grafting the proximal circumflex coronary artery (# 11)]. Kyobu Geka. 2001 Mar;54(3):215-8. Japanese.

著書 総説など

研究歴 (競争的研究経費)